http://www.abc.net.au/science/slab/shorter/story.htm
Platypus
For a shy little animal, the platypus (
Ornithorhynchus anatinus) can cause a lot of grief. Tucked away on the back legs of mature males are a pair of short spurs each hooked-up to a venom gland that makes a viciously painful toxin.
Platypus spurrings of people are rare, but the select group who have survived the trauma (often fishermen trying to free irate monotremes from their nets) report pain strong enough to induce vomiting which can persist for days, weeks or even months. The pain is resistant to morphine and other pain-killing drugs and anaesthesia of the main nerve from the spur site is often the only way to relieve the patient's suffering.
A witness to one of the first recorded platypus spurrings made these observations:
"... the pain was intense and almost paralysing. But for the administration of small doses of brandy, he would have fainted on the spot: as it was, it was half and hour before he could stand without support: by that time the arm was swollen to the shoulder, and quite useless, and the pain in the hand very severe." - W.W. Spicer (1876)
Professor Philip Kuchel, from Sydney University, says there are at least 25 components in the platypus venom, including a protein that lowers blood pressure causing shock, digestive enzymes called hyaluronidases and peptidases that dissolve body tissue helping the poison to spread, and a protein that increases blood-flow to the spur site causing severe swelling. The slight acidity of the venom adds further sting.
But the special ingredient in platypus venom that accounts for its outstanding pain-inducing qualities is thought to act directly on nerve cells that register pain, called nocioceptors. Greg de Plater, who discovered the compound recently at the John Curtin School of Medical Research in Canberra, says it works a bit like capsacin (the active ingredient in chillies that makes them taste hot) by stimulating electrical activity in the pain cells.
Why this placid animal swims around with such a nasty toxin hidden in its back legs is still something of a mystery - the platypus doesn't use its spurs to catch or kill prey as far as anyone can tell. Cliff Gallagher, an emeritus professor studying the platypus at Sydney's Taronga Zoo, says the toxin is most often used in deadly skirmishes between rival males to stake out territory and also as an "excruciatingly painful" defence mechanism.
Study on the toxin is continuing and, ultimately, Greg de Plater hopes an understanding of how the different components of the platypus venom work could lead to new treatments for chronic pain sufferers.